Stem Cell Medical Studies

Stem Cell Regenerative
Medical Studies and Literature

Below are some of the Regenerative Medicine medical literature and the Regenerative Medicine medical studies that show the effectiveness of the procedures.

Knee Regenerative Medicine Studies

Hip Regenerative Medicine Studies

Shoulder Regenerative Medicine Studies

Back Regenerative Medicine Studies

Elbow Regenerative Medicine Studies

Foot and Ankle Regenerative Medicine Studies

Wrist and Hand Regenerative Medicine Studies

Muscle and Tendon Regenerative Medicine Studies

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Knee Regenerative Medicine Studies

Stem Cell Therapy medical studies

Efficacy of mesenchymal stem cells injection for the management of knee osteoarthritis: a systematic review and meta-analysis; Xia P, Wang X, Lin Q, Li X; Int Orthop. 2015 Dec;39(12):2363-72. doi: 10.1007/s00264-015-2785-8. Epub 2015 May 6. Link to article

Bone Marrow Cellular Therapies: Novel Therapy for Knee OsteoarthritisPiuzzi NS, Khlopas A, Newman JM, Ng M, Roche M, Husni ME, Spindler KP, Mont MA, Muschler G.; J Knee Surg. 2018 Jan;31(1):22-26. doi: 10.1055/s-0037-1608844. Epub 2017 Nov 22. Link to article

Intra-articular injection of two different doses of autologous bone marrow mesenchymal stem cells versus hyaluronic acid in the treatment of knee osteoarthritis: multicenter randomized controlled clinical trial (phase I/II); Lamo-Espinosa JM, Mora G, Blanco JF, Granero-Moltó F, Nuñez-Córdoba JM,Et Al., J Transl Med. 2016 Aug 26;14(1):246. doi: 10.1186/s12967-016-0998-2. Link to article

Mesenchymal stem cell injections improve symptoms of knee osteoarthritis. Koh YG, Jo SB, Kwon OR, Suh DS, Lee SW, Park SH, Choi YJ. Arthroscopy. 2013 Apr;29(4):748-55. doi: 10.1016/j.arthro.2012.11.017. Epub 2013 Jan 29. Link to article

Long-Term Follow-up of Intra-articular Injection of Autologous Mesenchymal Stem Cells in Patients with Knee, Ankle or Hip Osteoarthritis. Emadedin M, Ghorbani Liastani M, Fazeli R, Mohseni F, Moghadasali R, Mardpour S, Hosseini SE, Niknejadi M, Moeininia F, Aghahossein Fanni A, Baghban Eslaminejhad R, Vosough Dizaji A, Labibzadeh N, Mirazimi Bafghi A, Baharvand H, Aghdami N. Arch Iran Med. 2015 Jun;18(6):336-44. doi: 015186/AIM.003. Link to article

Biological treatment of the knee with platelet-rich plasma or bone marrow aspirate concentrates. A review of the current status. Moatshe G, Morris RM, Cinque ME, Pascual-Garrido C, Chahla J, Engebretsen L, and Laprade RF. Acta Orthop. 2017 Nov; 88(6): 670–674. Link to article

A Prospective, Single-Blind, Placebo-Controlled Trial of Bone Marrow Aspirate Concentrate for Knee Osteoarthritis. Shapiro SA, Kazmerchak SE, Heckman MG, Zubair AC, O’Connor MI. Am J Sports Med. 2017 Jan;45(1):82-90. doi: 10.1177/0363546516662455. Epub 2016 Sep 30. Link to article

Comparative outcomes of open-wedge high tibial osteotomy with platelet-rich plasma alone or in combination with mesenchymal stem cell treatment: a prospective study. Koh YG, Kwon OR, Kim YS, Choi YJ. Arthroscopy. 2014 Nov;30(11):1453-60. doi: 10.1016/j.arthro.2014.05.036. Epub 2014 Aug 6. Link to article

Injection of platelet-rich plasma in patients with primary and secondary knee osteoarthritis: a pilot study. Sampson S, Reed M, Silvers H, Meng M, Mandelbaum B. Am J Phys Med Rehabil. 2010 Dec;89(12):961-9. doi: 10.1097/PHM.0b013e3181fc7edf. Link to article

Platelet-rich plasma (PRP) for knee disorders. Shahid M and Kundra R. EFORT Open Rev. 2017 Feb; 2(2): 28–34. Link to article

Effectiveness of platelet-rich plasma in the treatment of moderate knee osteoarthritis: a randomized prospective study. Kavadar G, Demircioglu DT, Celik MY, Emre TY. J Phys Ther Sci. 2015 Dec;27(12):3863-7. doi: 10.1589/jpts.27.3863. Epub 2015 Dec 28. Link to article

Platelet-rich plasma intra-articular injection versus hyaluronic acid viscosupplementation as treatments for cartilage pathology: from early degeneration to osteoarthritis. Kon E, Mandelbaum B, Buda R, Filardo G, Delcogliano M, Timoncini A, Fornasari PM, Giannini S, Marcacci M. 2011 Nov;27(11):1490-501. doi: 10.1016/j.arthro.2011.05.011. Epub 2011 Aug 10. Link to article

Clinical Applications of Platelet-Rich Plasma in Patellar Tendinopathy, D. U. Jeong, C.-R. Lee, J. H. Lee, J. Pak, L.-W. Kang, B. C. Jeong, and S. H. Lee,  Biomed Res Int. 2014; 2014: 249498; Published online 2014 Jul 21. doi:  10.1155/2014/249498; Link to article

Potential use of mesenchymal stem cells in human meniscal repair: current insights; Jaewoo Pak, Jung Hun Lee, Kwang Seung Park, Jeong Ho Jeon,and Sang Hee Lee; Open Access J Sports Med. 2017; 8: 33–38. Link to article

One-Stage Cartilage Repair Using a Hyaluronic Acid-Based Scaffold With Activated Bone Marrow-Derived Mesenchymal Stem Cells Compared With Microfracture: Five-Year Follow-up. Gobbi A, Whyte GP. Am J Sports Med. 2016 Nov;44(11):2846-2854. Epub 2016 Jul 29. Link to Article

A dose response analysis of a specific bone marrow concentrate treatment protocol for knee osteoarthritis. Centeno CJ, Al-Sayegh H, Bashir J, Goodyear S, Freeman MD. BMC Musculoskelet Disord. 2015 Sep 18;16:258. doi: 10.1186/s12891-015-0714 Link to Article

Treatment of Knee Meniscus Pathology: Rehabilitation, Surgery, and Orthobiologics; Chirichella PS, Jow S, Iacono S, Wey HE, Malanga GA; PM R. 2018 Sep 7. pii: S1934-1482(18)30857-8. doi: 10.1016/j.pmrj.2018.08.38. Link to article

Hip Regenerative Medicine Studies

Stem Cell Therapy medical studies

Ultrasound-Guided Injection of Platelet-Rich Plasma and Hyaluronic Acid, Separately and in Combination, for Hip Osteoarthritis: A Randomized Controlled Study; Dallari D, Stagni C, Rani N, Sabbioni G, Pelotti P, Torricelli P, Tschon M, Giavaresi G; Am J Sports Med. 2016 Mar;44(3):664-71. doi: 10.1177/0363546515620383. Epub 2016 Jan 21. Link to article

Mesenchymal stem cell therapy in the treatment of osteoarthritis: reparative pathways, safety and efficacy – a review; Freitag J, Bates D, Boyd R, Shah K, Barnard A, Huguenin L, Tenen A; BMC Musculoskelet Disord. 2016 May 26;17:230. doi: 10.1186/s12891-016-1085-9; Link to article

Mesenchymal stem cell therapy in the treatment of hip osteoarthritis. Mardones R, Jofré CM, Tobar L, Minguell JJ; J Hip Preserv Surg. 2017 Mar 19;4(2):159-163. doi: 10.1093/jhps/hnx011. eCollection 2017 Jul. Link to article

The role of “cell therapy” in osteonecrosis of the femoral head. A systematic review of the literature and meta-analysis of 7 studies; Papakostidis C, Tosounidis TH, Jones E, Giannoudis PV; Acta Orthop. 2016 Feb;87(1):72-8. doi: 10.3109/17453674.2015.1077418. Epub 2015 Jul 29. Link to article

Long-Term Follow-up of Intra-articular Injection of Autologous Mesenchymal Stem Cells in Patients with Knee, Ankle or Hip Osteoarthritis. Emadedin M, Ghorbani Liastani M, Fazeli R, Mohseni F, Moghadasali R, Mardpour S, Hosseini SE, Niknejadi M, Moeininia F, Aghahossein Fanni A, Baghban Eslaminejhad R, Vosough Dizaji A, Labibzadeh N, Mirazimi Bafghi A, Baharvand H, Aghdami N. Arch Iran Med. 2015 Jun;18(6):336-44. doi: 015186/AIM.003. Link to article

Cell therapy of hip osteonecrosis with autologous bone marrow grafting. Hernigou P, Poignard A, Zilber S, Rouard H. Indian J Orthop. 2009 Jan;43(1):40-5. doi: 10.4103/0019-5413.45322. Link to Article

Stem cell treatment for avascular necrosis of the femoral head: current perspectives. Houdek MT, Wyles CC, Martin JR, Sierra RJ. Stem Cells Cloning. 2014; 7: 65–70. Link to article

Shoulder Regenerative Medicine Studies

Stem Cell Therapy medical studies

Comparative Efficacy of Platelet Rich Plasma Injection, Corticosteroid Injection and Ultrasonic Therapy in the Treatment of Periarthritis Shoulder. Kothari SY, Srikumar V, Singh N; J Clin Diagn Res. 2017 May;11(5):RC15-RC18. doi: 10.7860/JCDR/2017/17060.9895. Epub 2017 May 1. Link to article

A prospective multi-site registry study of a specific protocol of autologous bone marrow concentrate for the treatment of shoulder rotator cuff tears and osteoarthritis; Centeno CJ, Al-Sayegh H, Bashir J, Goodyear S, Freeman MD; J Pain Res. 2015 Jun 5;8:269-76. doi: 10.2147/JPR.S80872. eCollection 2015. Link to article

Effect of Bone Marrow Aspirate Concentrate-Platelet-Rich Plasma on Tendon-Derived Stem Cells and Rotator Cuff Tendon Tear; Sun Jeong Kim, Da Hyun Song, Jong Wook Park, Silvia Park, and Sang Jun Kim; Cell Transplant. 2017 May; 26(5): 867–878. Published online 2017 May 1. doi:  10.3727/096368917X694705. Link to article

Back Regenerative Medicine Studies

Stem Cell Therapy medical studies

Autologous bone marrow concentrate intradiscal injection for the treatment of degenerative disc disease with three-year follow-up; Pettine KA, Suzuki RK, Sand TT, Murphy MB, Int Orthop. 2017 Oct;41(10):2097-2103. doi: 10.1007/s00264-017-3560-9. Epub 2017 Jul 26.  Link to article

Lumbar Intradiskal Platelet-Rich Plasma (PRP) Injections: A Prospective, Double-Blind, Randomized Controlled Study; Tuakli-Wosornu YA, Terry A, Boachie-Adjei K, Harrison JR, Gribbin CK, LaSalle EE, Nguyen JT, Solomon JL, Lutz GE; PM R. 2016 Jan;8(1):1-10; quiz 10. doi: 10.1016/j.pmrj.2015.08.010. Epub 2015 Aug 24. Link to article

Current understanding of safety and efficacy of stem cell therapy for discogenic pain—A systematic review of human studies; Hunt CL, Shen S, Nassr A, van Wijnen AJ, Larson AN, Eldrige JS, Mauck WD, Pingree MJ, Erwin PJ, Bydon M, Qu W; Tech in Reg Anes and Pain Mgmt. 2015 Jan V19:1-2, P32-37. Link to article

Lumbar Intradiskal Platelet-Rich Plasma (PRP) Injections: A Prospective, Double-Blind, Randomized Controlled Study. Tuakli-Wosornu YA, Terry A, Boachie-Adjei K, Harrison JR, Gribbin CK, LaSalle EE, Nguyen JT, Solomon JL, Lutz GE. PM R. 2016 Jan;8(1):1-10; quiz 10. doi: 10.1016/j.pmrj.2015.08.010. Epub 2015 Aug 24. Link to article

Elbow Regenerative Medicine Studies

Stem Cell Therapy medical studies

Platelet-rich plasma versus corticosteroid injection for recalcitrant lateral epicondylitis: clinical and ultrasonographic evaluation; Gautam VK, Verma S, Batra S, Bhatnagar N, Arora S; J Orthop Surg (Hong Kong). 2015 Apr;23(1):1-5. Link to article

A retrospective comparison of the management of recalcitrant lateral elbow tendinosis: platelet-rich plasma injections versus surgery; Ford RD, Schmitt WP, Lineberry K, Luce P.; Hand (N Y). 2015 Jun;10(2):285-91. doi: 10.1007/s11552-014-9717-8. Link to article

Platelet rich plasma versus laser therapy in lateral epicondylitis of elbow. Tonk G, Kumar A, Gupta A.; Indian J Orthop. 2014 Jul;48(4):390-3. doi: 10.4103/0019-5413.136260. Link to article

Foot and Ankle Regenerative Medicine Studies

Stem Cell Therapy medical studies

Long-Term Follow-up of Intra-articular Injection of Autologous Mesenchymal Stem Cells in Patients with Knee, Ankle or Hip Osteoarthritis. Emadedin M, Ghorbani Liastani M, Fazeli R, Mohseni F3, Moghadasali R, Mardpour S3, Hosseini SE, Niknejadi M, Moeininia F, Aghahossein Fanni A, Baghban Eslaminejhad R, Vosough Dizaji A, Labibzadeh N, Mirazimi Bafghi A, Baharvand H, Aghdami N. Arch Iran Med. 2015 Jun;18(6):336-44. doi: 015186/AIM.003. Link to article

Platelet-rich plasma injections for the treatment of refractory Achilles tendinopathy: results at 4 years; Filardo G, Kon E, Di Matteo B, Di Martino A, Tesei G, Pelotti P, Cenacchi A, Marcacci M; Blood Transfus. 2014 Oct;12(4):533-40. doi: 10.2450/2014.0289-13. Epub 2014 Jun 19. Link to article

The Effectiveness of Platelet-Rich Plasma in the Treatment of Tendinopathy: A Meta-analysis of Randomized Controlled Clinical Trials. Fitzpatrick J, Bulsara M, Zheng MH. Am J Sports Med. 2017 Jan;45(1):226-233. doi: 10.1177/0363546516643716. Epub 2016 Jul 21. Link to article

Wrist and Hand Regenerative Medicine Studies

Wrist Pain Stem Cell treatment

Stem Cells and Biological Approaches to Treatment of Wrist ProblemsAlphonsus K. S. Chong, MD and Min He, PhD; J Wrist Surg. 2013 Nov; 2(4): 315–318.; doi:  10.1055/s-0033-1357761. Link to article

Biologic Approaches to Problems of the Hand and Wrist; Steiner MM, Calandruccio JH.; Orthop Clin North Am. 2017 Jul;48(3):343-349. doi: 10.1016/j.ocl.2017.03.010. Epub 2017 Apr 7. Link to article

Investigating the Effect of Intra-articular Platelet-Rich Plasma Injection on Union: Pain and Function Improvement in Patients with Scaphoid Fracture; Hamid Namazi and Toomaj Kayedi; J Hand Microsurg. 2016 Dec; 8(3): 140–144. Published online 2016 Nov 30. doi:  10.1055/s-0036-1597088. Link to article

Investigating the effect of intra-articular PRP injection on pain and function improvement in patients with distal radius fracture.; Namazi H, Mehbudi A.; Orthop Traumatol Surg Res. 2016 Feb;102(1):47-52. doi: 10.1016/j.otsr.2015.11.002. Epub 2016 Jan 7. Link to article

Muscle and Tendon Regenerative Medicine Studies

Tendon Pain Stem Cell treatment

Efficacy of platelet-rich plasma injections for symptomatic tendinopathy: systematic review and meta-analysis of randomised injection-controlled trials; Larry E Miller, William R Parrish, Breana Roides, and Samir Bhattacharyya; BMJ Open Sport Exerc Med. 2017; 3(1): e000237; Link to article

Beneficial Effects of Autologous Bone Marrow-Derived Mesenchymal Stem Cells in Naturally Occurring Tendinopathy; Roger Kenneth Whealands Smith, Natalie Jayne Werling, Stephanie Georgina Dakin, Rafiqul Alam, Allen E. Goodship, and Jayesh Dudhia; PLoS One. 2013; 8(9): e75697. Link to article

Clinical Applications of Platelet-Rich Plasma in Patellar Tendinopathy, D. U. Jeong, C.-R. Lee, J. H. Lee, J. Pak, L.-W. Kang, B. C. Jeong, and S. H. Lee,  Biomed Res Int. 2014; 2014: 249498. Published online 2014 Jul 21. doi:  10.1155/2014/249498. Link to article

Effect of Bone Marrow Aspirate Concentrate-Platelet-Rich Plasma on Tendon-Derived Stem Cells and Rotator Cuff Tendon Tear; Sun Jeong Kim, Da Hyun Song, Jong Wook Park, Silvia Park, and Sang Jun Kim; Cell Transplant. 2017 May; 26(5): 867–878. Link to article

Platelet-rich plasma injections for the treatment of refractory Achilles tendinopathy: results at 4 years; Giuseppe Filardo, Elizaveta Kon, Berardo Di Matteo, Alessandro Di Martino, Giulia Tesei, Patrizia Pelotti, Annarita Cenacchi, and Maurilio Marcacci1 Blood Transfus. 2014 Oct; 12(4): 533–540. Link to article

ENJOY LIFE AGAIN WITHOUT PAIN OR SURGERY

Find out if you are eligible for our treatments.

Is Stem Cell Treatment Right For You?

Although Stem Cell Treatment is considered by some people to be experimental, various research studies show that regenerative stem cell therapy and platelet rich plasma injections can provide excellent relief from joint and musculoskeletal pain and ongoing inflammation.

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